In-vitro dermal absorption
This webinar provides a clear and practical overview of in vitro skin penetration studies conducted in accordance with OECD Guideline 428 and EFSA 2017 guidance. It covers radiolabeled and non‑radiolabeled approaches, the analysis of skin compartments, and specific considerations for volatile, photosensitive, or hydrolysis‑sensitive substances in a regulatory context.
Objectives and skills
By the end of the webinar, participants will be able to:
- Understand the key steps of an in vitro dermal absorption study, including methodological choices, static vs dynamic systems, occlusion conditions, receptor fluid selection, and analytical validation.
- Identify the strengths and limitations of radiolabeled versus non‑radiolabeled approaches.
- Recognize analytical and methodological challenges associated with volatile, photosensitive, or hydrolysis‑sensitive substances.
- Assess the quality and regulatory acceptability of data generated for submission dossiers.
Public and prerequisites
Target audience:
- Regulatory affairs professionals
- Toxicologists and product safety experts
- R&D scientists (cosmetics, biocides, agrochemicals, pharmaceuticals)
- Project or quality managers involved in dermal absorption studies
Prerequisites:
No strict prerequisite. General knowledge of in vitro studies or regulatory frameworks is helpful but not required.
Program/Content
Overview of OECD 428 & EFSA 2017 guidance ;
Key methodological choices
- Static vs dynamic diffusion cells
- Occlusion conditions
- Receptor fluid selection
Analytical approaches
- Radiolabeled studies
- Non‑radiolabeled studies
Analysis of skin compartments
- Stratum corneum, epidermis, dermis, receptor
Specific cases & technical challenges
- Highly volatile substances
- Photosensitive actives
- Hydrolysis‑sensitive compounds
Best practices & regulatory requirements
- Generating robust and acceptable data for authorities
Details and technical aspects
- Date: November 19th, 2026
- Training duration: +/- 1h30
- Time: 9h30 - 11h30
- Language of presentation : English
- Language of training material : English
- Online training
- Cost : 350€
- Minimum number of participants : the training will be held based on a minimum of 5 participants.
- Participation fee is for ONE participant (Fees are to be paid individually for each participant).
- A 10% discount will be applied to the price from the second participant from the same company in the same training. Please register the first participant and contact rraacademy@redebel.com to receive the promocode.
19.11.26
English
English
Online
1 hours
350.00€ Excl. Tax
